Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Htr6. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Htr6
  • is located in the following cellular components:
    • cilium ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Htr6:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
    • learning
    • long-term synaptic potentiation
    • negative regulation of acetylcholine secretion
    • negative regulation of gamma-aminobutyric acid secretion
    • negative regulation of glutamate secretion
    • positive regulation of dopamine secretion
    • positive regulation of gamma-aminobutyric acid secretion
    • serotonin receptor signaling pathway
  • performs the following molecular functions:
    • serotonin receptor activity
  • is located in the following cellular components:
    • dendrite
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Htr6 encodes a protein or proteins that contain the following InterPro domains: GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Htr6 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Chih B et al. (2011) A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat Cell Biol, 14:61-72. (PubMed:22179047)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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