Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 3.1.1)

Exhibits exonuclease activity. Involved in aging and mitochondrial DNA replication. Localizes to mitochondrial inner membrane. Is expressed in several structures, including early conceptus and secondary oocyte. Used to study bipolar disorder; mood disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. Orthologous to human POLG (DNA polymerase gamma, catalytic subunit).

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Gene Ontology Evidence Code Abbreviations:

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