Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Arhgap6. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Arhgap6
  • participates in the following biological processes:
    • actin filament organization ^[1]
    • focal adhesion assembly ^[1]
    • positive regulation of GTPase activity ^[1]
    • regulation of GTPase activity ^[1]
  • performs the following molecular functions:
    • Rho GTPase activator activity ^[1]
  • is located in the following cellular components:
    • actin cytoskeleton ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Arhgap6:
  • participates in the following biological processes:
    • activation of phospholipase C activity
    • negative regulation of focal adhesion assembly
    • negative regulation of stress fiber assembly
    • positive regulation of phospholipase activity
  • performs the following molecular functions:
    • phospholipase activator activity
    • phospholipase binding
  • is located in the following cellular components:
    • cytoplasm

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Summary text based on GO annotations supported by structural data

• Arhgap6 encodes a protein or proteins that contain the following InterPro domains: Rho GTPase activation protein, Rho GTPase-activating protein domain, indicating that the gene product:
  • participates in the following biological processes:
    • signal transduction
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Arhgap6 indicates that it:
  • performs the following molecular functions:
    • GTPase activator activity
    • SH3 domain binding

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References

1. Prakash SK et al. (2000) Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Hum Mol Genet, 9:477-88. (PubMed:10699171)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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