Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables signaling receptor activity. Involved in cell death in response to hydrogen peroxide. Located in postsynaptic density. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 16 and distal spinal muscular atrophy 2. Orthologous to human SIGMAR1 (sigma non-opioid intracellular receptor 1).