Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sigmar1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Sigmar1
  • performs the following molecular functions:
    • receptor activity ^[3]
• The gene product of Sigmar1 has been shown to bind to the gene products of Kcna2. ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Sigmar1:
  • participates in the following biological processes:
    • nervous system development
    • opioid receptor signaling pathway
    • regulation of neuron apoptotic process
  • performs the following molecular functions:
    • opioid receptor activity
  • is located in the following cellular components:
    • nuclear envelope

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Summary text based on GO annotations supported by structural data

• Sigmar1 encodes a protein or proteins that contain the following InterPro domains: ERG2/sigma1 receptor-like, indicating that the gene product:
  • participates in the following biological processes:
    • lipid transport

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sigmar1 indicates that it:
  • participates in the following biological processes:
    • lipid transport
    • transport
  • is located in the following cellular components:
    • cell junction
    • cell projection
    • endoplasmic reticulum
    • integral component of membrane
    • lipid particle
    • membrane
    • nucleus
    • plasma membrane

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References

1. Hayashi T et al. (2007) Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell, 131:596-610. (PubMed:17981125)
2. Kourrich S et al. (2013) Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell, 152:236-47. (PubMed:23332758)
3. Langa F et al. (2003) Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice. Eur J Neurosci, 18:2188-96. (PubMed:14622179)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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