Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kcnj10. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of January 10, 2011. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Kcnj10
  • participates in the following biological processes:
    • potassium ion transmembrane transport ^[4]
    • potassium ion transport ^[4]
  • performs the following molecular functions:
    • potassium channel activity ^[4]
  • is located in the following cellular components:
    • basolateral plasma membrane ^[6]
    • plasma membrane ^[2]
• The gene product of Kcnj10 has been shown to bind to the gene products of Inadl, Snta1, Sntb1, Sntb2. ^{[2, 4]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Kcnj10
  • participates in the following biological processes:
    • adult walking behavior ^{[1, 3]}
    • central nervous system myelination ^[1]
    • L-glutamate uptake involved in synaptic transmission ^[1]
    • oligodendrocyte development ^[1]
    • potassium ion homeostasis ^{[1, 5]}
    • potassium ion transmembrane transport ^{[3, 7, 8, 10]}
    • regulation of ion transmembrane transport ^[8]
    • regulation of long-term neuronal synaptic plasticity ^[1]
    • regulation of membrane potential ^{[7, 8]}
    • regulation of resting membrane potential ^{[1, 3, 5]}
    • visual perception ^{[3, 9]}
  • performs the following molecular functions:
    • inward rectifier potassium channel activity ^{[7, 8]}
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Kcnj10
  • is located in the following cellular components:
    • integral component of plasma membrane ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Kcnj10:
  • participates in the following biological processes:
    • L-glutamate import
    • membrane hyperpolarization
    • potassium ion import
    • potassium ion transmembrane transport
    • protein homotetramerization
    • regulation of sensory perception of pain
  • performs the following molecular functions:
    • identical protein binding
    • inward rectifier potassium channel activity
    • receptor binding
  • is located in the following cellular components:
    • apical plasma membrane
    • astrocyte projection
    • basolateral plasma membrane
    • microvillus

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Summary text based on GO annotations supported by structural data

• Kcnj10 encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin E-set, Potassium channel, inwardly rectifying, Kir, Potassium channel, inwardly rectifying, Kir, cytoplasmic, Potassium channel, inwardly rectifying, Kir1.2, indicating that the gene product:
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kcnj10 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • ATP binding
    • nucleotide binding
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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References

1. Djukic B et al. (2007) Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation. J Neurosci, 27:11354-65. (PubMed:17942730)
2. Hibino H et al. (2004) Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes. J Biol Chem, 279:44065-73. (PubMed:15310750)
3. Kofuji P et al. (2000) Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina. J Neurosci, 20:5733-40. (PubMed:10908613)
4. Kurschner C et al. (1998) CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Mol Cell Neurosci, 11:161-72. (PubMed:9647694)
5. Neusch C et al. (2006) Lack of the Kir4.1 channel subunit abolishes K+ buffering properties of astrocytes in the ventral respiratory group: impact on extracellular K+ regulation. J Neurophysiol, 95:1843-52. (PubMed:16306174)
6. Reichold M et al. (2010) KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function. Proc Natl Acad Sci U S A, 107:14490-5. (PubMed:20651251)
7. Seifert G et al. (2009) Analysis of astroglial K+ channel expression in the developing hippocampus reveals a predominant role of the Kir4.1 subunit. J Neurosci, 29:7474-88. (PubMed:19515915)
8. Tang X et al. (2010) Inwardly rectifying potassium channel Kir4.1 is responsible for the native inward potassium conductance of satellite glial cells in sensory ganglia. Neuroscience, 166:397-407. (PubMed:20074622)
9. Wu J et al. (2004) Contribution of Kir4.1 to the mouse electroretinogram. Mol Vis, 10:650-4. (PubMed:15359216)
10. Zhang H et al. (2008) Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells. Mol Cell Neurosci, 37:1-10. (PubMed:17869537)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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