Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tgif1. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 16, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tgif1
  • participates in the following biological processes:
    • positive regulation of neuron differentiation ^[6]
    • retina development in camera-type eye ^[6]
  • performs the following molecular functions:
    • chromatin binding ^[1]
  • is located in the following cellular components:
    • nucleus ^[2]
• The gene product of Tgif1 has been shown to bind to the gene products of Rxra. ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Tgif1
  • participates in the following biological processes:
    • determination of left/right symmetry ^[4]
    • dorsal/ventral pattern formation ^[3]
    • negative regulation of cell proliferation ^[3]
    • negative regulation of retinoic acid receptor signaling pathway ^[1]
    • neural tube closure ^[3]
    • positive regulation of fibroblast proliferation ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Tgif1
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter based on interactions with Rxra ^[1]
    • nodal signaling pathway based on interactions with Tgif2 ^[5]
    • regulation of gastrulation based on interactions with Nodal, Tgif2 ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tgif1:
  • participates in the following biological processes:
    • negative regulation of gene expression
    • negative regulation of transcription from RNA polymerase II promoter
  • performs the following molecular functions:
    • co-SMAD binding
    • JUN kinase binding
  • is located in the following cellular components:
    • nucleus

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Summary text based on GO annotations supported by structural data

• Tgif1 encodes a protein or proteins that contain the following InterPro domains: Homeobox KN domain, Homeodomain, Homeodomain-like, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tgif1 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding

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References

1. Bartholin L et al. (2006) TGIF inhibits retinoid signaling. Mol Cell Biol, 26:990-1001. (PubMed:16428452)
2. Davis H et al. (2011) FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J Pathol, 224:180-9. (PubMed:21503901)
3. Kuang C et al. (2006) Intragenic deletion of Tgif causes defectsin brain development. Hum Mol Genet, 15:3508-19. (PubMed:17082251)
4. Mar L et al. (2006) Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling. Mol Cell Biol, 26:4302-10. (PubMed:16705179)
5. Powers SE et al. (2010) Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development, 137:249-59. (PubMed:20040491)
6. Zaman V et al. (2008) The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior. Eur J Neurosci, 28:1557-68. (PubMed:18973577)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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