Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Thbs4. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 5, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Thbs4:
  • participates in the following biological processes:
    • endothelial cell-cell adhesion
    • myoblast migration
    • nervous system development
    • neuron projection morphogenesis
    • positive regulation of endothelial cell proliferation
    • positive regulation of neutrophil chemotaxis
    • positive regulation of peptidyl-tyrosine phosphorylation
    • protein homooligomerization
  • performs the following molecular functions:
    • calcium ion binding
    • collagen binding
    • fibronectin binding
    • heparin binding
    • integrin binding
    • laminin-1 binding
  • is located in the following cellular components:
    • basement membrane
    • extracellular space
    • neuromuscular junction
    • proteinaceous extracellular matrix

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Summary text based on GO annotations supported by structural data

• Thbs4 encodes a protein or proteins that contain the following InterPro domains: Concanavalin A-like lectin/glucanase, subgroup, Concanavalin A-like lectin/glucanases superfamily, EGF-like calcium-binding, EGF-like calcium-binding, conserved site, EGF-like, conserved site, Epidermal growth factor-like domain, Laminin G domain, Thrombospondin, C-terminal, Thrombospondin, type 3 repeat, Thrombospondin, type 3-like repeat, Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Thbs4 indicates that it:
  • participates in the following biological processes:
    • cell adhesion
    • positive regulation of cell division
  • performs the following molecular functions:
    • growth factor activity

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References

1. Lynch JM et al. (2012) A thrombospondin-dependent pathway for a protective ER stress response. Cell, 149:1257-68. (PubMed:22682248)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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