Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables chromatin binding activity and histone H2AK119 ubiquitin ligase activity. Involved in germ cell development and negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within anterior/posterior axis specification; gastrulation with mouth forming second; and mitotic cell cycle. Located in nuclear body. Part of PRC1 complex; euchromatin; and sex chromatin. Is active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; limb; and retina. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to human RNF2 (ring finger protein 2).