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Gene Ontology Classifications
paired-like homeobox 2b

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Phox2b. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bates MD et al. (2006) The Hlx homeobox transcription factor is required early in enteric nervous system development. BMC Dev Biol, 6:33. (PubMed:16854219)
  2. Coppola E et al. (2005) Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiation. EMBO J, 24:4392-403. (PubMed:16319924)
  3. Coppola E et al. (2010) Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation. Development, 137:4211-20. (PubMed:21068058)
  4. Dubreuil V et al. (2009) Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons. J Neurosci, 29:14836-46. (PubMed:19940179)
  5. Huber K et al. (2005) The role of Phox2B in chromaffin cell development. Dev Biol, 279:501-8. (PubMed:15733675)
  6. Jacob J et al. (2007) Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci, 10:1433-9. (PubMed:17922007)
  7. Morikawa Y et al. (2009) BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development, 136:3575-84. (PubMed:19793887)
  8. Nekrep N et al. (2008) Signals from the neural crest regulate beta-cell mass in the pancreas. Development, 135:2151-60. (PubMed:18506029)
  9. Pattyn A et al. (1999) The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature, 399:366-70. (PubMed:10360575)
  10. Rajan S et al. (2011) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol Genomics, null:null. (PubMed:22147266)
  11. Tiveron MC et al. (2003) Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus. Dev Biol, 260:46-57. (PubMed:12885554)
  12. Wildner H et al. (2008) Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage. Development, 135:473-81. (PubMed:18094025)
  13. Yokoyama M et al. (1999) Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation. Genomics, 59:40-50. (PubMed:10395798)
  14. Young HM et al. (1998) A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture. Dev Biol, 202:67-84. (PubMed:9758704)
  15. Young HM et al. (1999) Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut. Dev Dyn, 216:137-52. (PubMed:10536054)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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