Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Prss12. (This text reflects annotations as of Wednesday, August 14, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 16, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). [provided by RefSeq, Jul 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Prss12
  • participates in the following biological processes:
    • exocytosis ^[1]
    • proteolysis ^[2]
    • zymogen activation ^[2]
  • performs the following molecular functions:
    • serine-type endopeptidase activity ^[2]
  • is located in the following cellular components:
    • axon ^[1]
    • cytoplasmic vesicle ^[2]
    • dendrite ^[2]
    • plasma membrane ^[1]
    • synapse ^[4]
    • synaptic cleft ^[1]
    • terminal bouton ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Prss12
  • participates in the following biological processes:
    • proteolysis ^{[3, 4]}
  • performs the following molecular functions:
    • peptidase activity ^{[3, 4]}

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Summary text based on GO annotations supported by structural data

• Prss12 encodes a protein or proteins that contain the following InterPro domains: Kringle, Kringle, conserved site, Kringle-like fold, Peptidase S1, Peptidase S1, trypsin family, active site, Peptidase S1A, chymotrypsin-type, Speract/scavenger receptor, Speract/scavenger receptor-related, Trypsin-like cysteine/serine peptidase domain, indicating that the gene product:
  • performs the following molecular functions:
    • catalytic activity
    • scavenger receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Prss12 indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • serine-type peptidase activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Frischknecht R et al. (2008) Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. J Neurosci, 28:1568-79. (PubMed:18272678)
2. Mitsui S et al. (2007) Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation. Brain Res, 1136:1-12. (PubMed:17223089)
3. Reif R et al. (2007) Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation. FASEB J, 21:3468-78. (PubMed:17586728)
4. Stephan A et al. (2008) Neurotrypsin cleaves agrin locally at the synapse. FASEB J, 22:1861-73. (PubMed:18230682)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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