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Gene Ontology Classifications
Symbol
Name
ID
Prss12
protease, serine 12 neurotrypsin (motopsin)
MGI:1100881

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GO curators for mouse genes have assigned the following annotations to the gene product of Prss12. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 16, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). [provided by RefSeq, Jul 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Frischknecht R et al. (2008) Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. J Neurosci, 28:1568-79. (PubMed:18272678)
  2. Mitsui S et al. (2007) Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation. Brain Res, 1136:1-12. (PubMed:17223089)
  3. Reif R et al. (2007) Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation. FASEB J, 21:3468-78. (PubMed:17586728)
  4. Stephan A et al. (2008) Neurotrypsin cleaves agrin locally at the synapse. FASEB J, 22:1861-73. (PubMed:18230682)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory