Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Prss12. (This text reflects annotations as of Tuesday, July 8, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). [provided by RefSeq, Jul 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Prss12
  • participates in the following biological processes:
    • exocytosis ^[]
    • proteolysis ^[]
    • zymogen activation ^[]
  • performs the following molecular functions:
    • serine-type endopeptidase activity ^[]
  • is located in the following cellular components:
    • axon ^[]
    • cytoplasmic vesicle ^[]
    • dendrite ^[]
    • plasma membrane ^[]
    • synapse ^[]
    • synaptic cleft ^[]
    • terminal bouton ^[]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Prss12
  • participates in the following biological processes:
    • proteolysis ^{[, ]}
  • performs the following molecular functions:
    • peptidase activity ^{[, ]}

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Summary text based on GO annotations supported by structural data

• Prss12 encodes a protein or proteins that contain the following InterPro domains: indicating that the gene product:
  • performs the following molecular functions:
    • catalytic activity
    • scavenger receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Prss12 indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • serine-type peptidase activity
  • is located in the following cellular components:
    • extracellular region

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References

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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