Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gcnt2. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gcnt2
  • participates in the following biological processes:
    • metabolic process ^[1]
  • performs the following molecular functions:
    • acetylglucosaminyltransferase activity ^[1]

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Summary text based on GO annotations supported by structural data

• Gcnt2 encodes a protein or proteins that contain the following InterPro domains: Glycosyl transferase, family 14, indicating that the gene product:
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gcnt2 indicates that it:
  • performs the following molecular functions:
    • transferase activity
    • transferase activity, transferring glycosyl groups
  • is located in the following cellular components:
    • Golgi apparatus
    • integral to membrane
    • membrane
• Gcnt2 has been associated with the Enzyme Commission numbers: 2.4.1.150, which implies that the gene product:
  • performs the following molecular functions:
    • N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity

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References

1. Twu YC et al. (2003) The molecular genetics of the mouse I beta-1,6-N-acetylglucosaminyltransferase locus. Biochem Biophys Res Commun, 303:868-76. (PubMed:12670491)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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