GO curators for mouse genes have assigned the following annotations to the gene product of Dnah11. (This text reflects annotations as of Thursday, July 24, 2014.) Summary from NCBI RefSeq
[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]Summary text based on GO annotations supported by experimental evidence in mouse
Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Dnah11
participates in the following biological processes:
Hummel KP et al. (1959) Visceral inversion and associated anomalies in the mouse J Hered, 50:9-13.
Supp DM et al. (1997) Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice. Nature, 389:963-6. (PubMed:9353118)
Supp DM et al. (1999) Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries. Development, 126:5495-504. (PubMed:10556073)