Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dnahc11. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Dnahc11
  • participates in the following biological processes:
    • ciliary or flagellar motility ^[2]
    • metabolic process ^[2]
  • performs the following molecular functions:
    • microtubule motor activity ^[2]
  • is located in the following cellular components:
    • axonemal dynein complex ^[2]
    • cilium ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Dnahc11
  • participates in the following biological processes:
    • determination of left/right symmetry ^{[1, 2]}

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Dnahc11 indicates that it:
  • performs the following molecular functions:
    • ATP binding
    • nucleotide binding

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References

1. Supp DM et al. (1997) Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice. Nature, 389:963-6. (PubMed:9353118)
2. Supp DM et al. (1999) Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries. Development, 126:5495-504. (PubMed:10556073)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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