Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Capn5. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by structural data

• Capn5 encodes a protein or proteins that contain the following InterPro domains: C2 calcium-dependent membrane targeting, C2 calcium/lipid-binding domain, CaLB, Cysteine peptidase, cysteine active site, Peptidase C2, calpain family, Peptidase C2, calpain, catalytic domain, Peptidase C2, calpain, domain III, Peptidase C2, calpain, large subunit, domain III, indicating that the gene product:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • calcium-dependent cysteine-type endopeptidase activity
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Capn5 indicates that it:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • cysteine-type peptidase activity
    • hydrolase activity
    • peptidase activity

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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