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Gene Ontology Classifications
Symbol
Name
ID
Lmx1b
LIM homeobox transcription factor 1 beta
MGI:1100513

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lmx1b. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Deng Q et al. (2011) Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development, 138:3399-408. (PubMed:21752929)
  2. Ding YQ et al. (2003) Lmx1b is essential for the development of serotonergic neurons. Nat Neurosci, 6:933-8. (PubMed:12897786)
  3. Ding YQ et al. (2004) Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord. Development, 131:3693-703. (PubMed:15229182)
  4. Gu WX et al. (2010) Identification of genes controlled by LMX1B in E13.5 mouse limbs. Dev Dyn, null:null. (PubMed:20589901)
  5. Guo C et al. (2007) Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Development, 134:317-25. (PubMed:17166916)
  6. Kittappa R et al. (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol, 5:e325. (PubMed:18076286)
  7. Liu P et al. (2010) Lmx1b is required for murine trabecular meshwork formation and for maintenance of corneal transparency. Dev Dyn, null:null. (PubMed:20568247)
  8. Pressman CL et al. (2000) LMX1B, a LIM homeodomain class transcription factor, is necessary for normal development of multiple tissues in the anterior segment of the murine eye. Genesis, 26:15-25. (PubMed:10660670)
  9. Zhao ZQ et al. (2006) Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci, 26:12781-8. (PubMed:17151281)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory