Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mre11a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Mre11a
  • is located in the following cellular components:
    • nucleus ^{[2, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mre11a
  • participates in the following biological processes:
    • cell cycle checkpoint ^{[4, 5]}
    • cell proliferation ^[6]
    • chromosome organization ^[5]
    • double-strand break repair ^[1]
    • synapsis ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Mre11a:
  • participates in the following biological processes:
    • DNA duplex unwinding
    • negative regulation of DNA endoreduplication
    • positive regulation of kinase activity
    • positive regulation of protein autophosphorylation
    • response to DNA damage stimulus
    • sister chromatid cohesion
  • performs the following molecular functions:
    • protein C-terminus binding
  • is located in the following cellular components:
    • condensed nuclear chromosome
    • Mre11 complex
    • nuclear chromatin
    • nucleoplasm
    • nucleus
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Mre11a encodes a protein or proteins that contain the following InterPro domains: DNA repair protein Mre11, Metallophosphoesterase domain, Mre11, DNA-binding, indicating that the gene product:
  • participates in the following biological processes:
    • DNA metabolic process
  • performs the following molecular functions:
    • endonuclease activity
    • exonuclease activity
    • hydrolase activity
    • manganese ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mre11a indicates that it:
  • participates in the following biological processes:
    • DNA repair
    • meiosis
  • performs the following molecular functions:
    • endonuclease activity
    • exonuclease activity
    • hydrolase activity
    • nuclease activity

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References

1. Cherry SM et al. (2007) The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr Biol, 17:373-8. (PubMed:17291760)
2. Franchitto A et al. (2003) The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. Oncogene, 22:2110-20. (PubMed:12687013)
3. Sengupta S et al. (2004) Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol, 166:801-13. (PubMed:15364958)
4. Stracker TH et al. (2008) Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell, 31:21-32. (PubMed:18614044)
5. Theunissen JW et al. (2003) Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell, 12:1511-23. (PubMed:14690604)
6. Xiao Y et al. (1997) Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res, 25:2985-91. (PubMed:9224597)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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