Automated description from the Alliance of Genome Resources
Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including lens development in camera-type eye; nervous system development; and positive regulation of transcription by RNA polymerase II. Localizes to the nucleus. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; cataract; cataract 11 multiple types; and cataract 9 multiple types. Is expressed in several structures, including alimentary system; brain; eye; limb; and musculoskeletal system. Orthologous to human PITX3 (paired like homeodomain 3).