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Gene Ontology Classifications
paired-like homeodomain transcription factor 3

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pitx3. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Ho HY et al. (2009) Homeodomain protein Pitx3 maintains the mitotic activity of lens epithelial cells. Mech Dev, 126:18-29. (PubMed:19007884)
  2. Jacobs FM et al. (2009) Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. Development, 136:2363-73. (PubMed:19515692)
  3. Jacobs FM et al. (2009) Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development, 136:531-40. (PubMed:19144721)
  4. Kas MJ et al. (2008) Phenotypic segregation of aphakia and Pitx3-null mutants reveals that Pitx3 deficiency increases consolidation of specific movement components Behav Brain Res, 186:208-14. (PubMed:17919745)
  5. Kim J et al. (2007) A MicroRNA feedback circuit in midbrain dopamine neurons. Science, 317:1220-4. (PubMed:17761882)
  6. Lebel M et al. (2001) Pitx3 activates mouse tyrosine hydroxylase promoter via a high-affinity binding site. J Neurochem, 77:558-67. (PubMed:11299318)
  7. Maxwell SL et al. (2005) Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development. Dev Biol, 282:467-79. (PubMed:15950611)
  8. Medina-Martinez O et al. (2009) Pitx3 controls multiple aspects of lens development. Dev Dyn, 238:2193-2201. (PubMed:19334279)
  9. Messmer K et al. (2007) Induction of tyrosine hydroxylase expression by the transcription factor Pitx3. Int J Dev Neurosci, 25:29-37. (PubMed:17184956)
  10. Smidt MP et al. (2004) Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development, 131:1145-55. (PubMed:14973278)
  11. Veenvliet JV et al. (2013) Specification of dopaminergic subsets involves interplay of En1 and Pitx3. Development, 140:3373-84. (PubMed:23863478)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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