Automated description from the Alliance of Genome Resources
Exhibits several functions, including ATPase binding activity; cation channel activity; and identical protein binding activity. Involved in several processes, including animal organ development; detection of nodal flow; and inorganic cation transmembrane transport. Localizes to several cellular components, including the basal cortex; microtubule cytoskeleton; and polycystin complex. Colocalizes with the cell-cell junction. Used to study autosomal dominant polycystic kidney disease; polycystic kidney disease 1; and polycystic kidney disease 2. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; early conceptus; and genitourinary system. Orthologous to human PKD2 (polycystin 2, transient receptor potential cation channel).