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Gene Ontology Classifications
fibroblast growth factor 10

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fgf10. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Aggarwal VS et al. (2006) Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. Hum Mol Genet, 15:3219-28. (PubMed:17000704)
  2. Alvarez Y et al. (2003) Requirements for FGF3 and FGF10 during inner ear formation. Development, 130:6329-38. (PubMed:14623822)
  3. Asaki T et al. (2004) Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo. Mol Cell Endocrinol, 218:119-28. (PubMed:15130516)
  4. Beer HD et al. (2005) The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Oncogene, 24:5269-77. (PubMed:15806171)
  5. Beer HD et al. (1997) Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression. Oncogene, 15:2211-8. (PubMed:9393979)
  6. Bellusci S et al. (1997) Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development, 124:4867-78. (PubMed:9428423)
  7. Beyer TA et al. (2003) Fibroblast growth factor 22 and its potential role during skin development and repair. Exp Cell Res, 287:228-36. (PubMed:12837279)
  8. Burns RC et al. (2004) Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse. Dev Biol, 265:61-74. (PubMed:14697353)
  9. De Langhe SP et al. (2006) Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol, 299:52-62. (PubMed:16989802)
  10. Del Moral PM et al. (2006) VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev Biol, 290:177-88. (PubMed:16375885)
  11. Donjacour AA et al. (2003) FGF-10 plays an essential role in the growth of the fetal prostate. Dev Biol, 261:39-54. (PubMed:12941620)
  12. Entesarian M et al. (2005) Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands. Nat Genet, 37:125-7. (PubMed:15654336)
  13. Fairbanks TJ et al. (2004) A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway. J Surg Res, 120:201-9. (PubMed:15234214)
  14. Fairbanks TJ et al. (2004) Fibroblast growth factor 10 (Fgf10) invalidation results in anorectal malformation in mice. J Pediatr Surg, 39:360-5; discussion 360-5. (PubMed:15017552)
  15. Govindarajan V et al. (2000) Endogenous and ectopic gland induction by FGF-10. Dev Biol, 225:188-200. (PubMed:10964474)
  16. Grishina IB et al. (2005) BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev Biol, 288:334-47. (PubMed:16324690)
  17. Harada H et al. (2002) FGF10 maintains stem cell compartment in developing mouse incisors. Development, 129:1533-41. (PubMed:11880361)
  18. Haraguchi R et al. (2000) Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation. Development, 127:2471-9. (PubMed:10804187)
  19. Hecksher-Sorensen J et al. (2004) The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2. Development, 131:4665-75. (PubMed:15329346)
  20. Hyatt BA et al. (2004) FGF-10 induces SP-C and Bmp4 and regulates proximal-distal patterning in embryonic tracheal epithelium. Am J Physiol Lung Cell Mol Physiol, 287:L1116-26. (PubMed:15531758)
  21. Jaskoll T et al. (2005) FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev Biol, 5:11. (PubMed:15972105)
  22. Kumagai A et al. (2003) Tumor chemopreventive activity of 3-O-acylated (-)-epigallocatechins. Bioorg Med Chem, 11:5143-8. (PubMed:14604677)
  23. Kuslak SL et al. (2007) The mouse seminal vesicle shape mutation is allelic with Fgfr2. Development, 134:557-65. (PubMed:17202188)
  24. Li C et al. (2005) Wnt5a regulates Shh and Fgf10 signaling during lung development. Dev Biol, 287:86-97. (PubMed:16169547)
  25. Mailleux AA et al. (2002) Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development, 129:53-60. (PubMed:11782400)
  26. Mailleux AA et al. (2001) Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis. Mech Dev, 102:81-94. (PubMed:11287183)
  27. Mailleux AA et al. (2005) Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development, 132:2157-66. (PubMed:15800000)
  28. Makarenkova HP et al. (2000) FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development, 127:2563-72. (PubMed:10821755)
  29. Min H et al. (1998) Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev, 12:3156-61. (PubMed:9784490)
  30. Norgaard GA et al. (2003) FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol, 264:323-38. (PubMed:14651921)
  31. Ohuchi H et al. (2000) FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem Biophys Res Commun, 277:643-9. (PubMed:11062007)
  32. Ohuchi H et al. (2005) Identification of cis-element regulating expression of the mouse Fgf10 gene during inner ear development. Dev Dyn, 233:177-87. (PubMed:15765517)
  33. Ohuchi H et al. (2003) Fibroblast growth factor 10 is required for proper development of the mouse whiskers. Biochem Biophys Res Commun, 302:562-7. (PubMed:12615071)
  34. Pauley S et al. (2006) Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear. Dev Dyn, 235:2470-2482. (PubMed:16691564)
  35. Petiot A et al. (2003) A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development, 130:5493-501. (PubMed:14530295)
  36. Petiot A et al. (2005) Development of the mammalian urethra is controlled by Fgfr2-IIIb. Development, 132:2441-50. (PubMed:15843416)
  37. Que J et al. (2007) Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development, 134:2521-31. (PubMed:17522155)
  38. Ramasamy SK et al. (2007) Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev Biol, 307:237-47. (PubMed:17560563)
  39. Rice R et al. (2004) Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest, 113:1692-700. (PubMed:15199404)
  40. Sahara S et al. (2009) Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors. Neuron, 63:48-62. (PubMed:19607792)
  41. Sakaue H et al. (2002) Requirement of fibroblast growth factor 10 in development of white adipose tissue. Genes Dev, 16:908-12. (PubMed:11959839)
  42. Sala FG et al. (2006) Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Dev Biol, 299:373-85. (PubMed:16956603)
  43. Sekine K et al. (1999) Fgf10 is essential for limb and lung formation. Nat Genet, 21:138-41. (PubMed:9916808)
  44. Spencer-Dene B et al. (2006) Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling. Gastroenterology, 130:1233-44. (PubMed:16618415)
  45. Suzuki K et al. (2000) Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene. FEBS Lett, 481:53-6. (PubMed:10984614)
  46. Suzuki K et al. (2002) Embryonic development of mouse external genitalia: insights into a unique mode of organogenesis. Evol Dev, 4:133-41. (PubMed:12004962)
  47. Tang N et al. (2011) Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science, 333:342-5. (PubMed:21764747)
  48. Tao H et al. (2005) A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development. Development, 132:3217-30. (PubMed:15958512)
  49. Veltmaat JM et al. (2006) Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development, 133:2325-35. (PubMed:16720875)
  50. Wright TJ et al. (2003) Fgf3 and Fgf10 are required for mouse otic placode induction. Development, 130:3379-90. (PubMed:12810586)
  51. Yamamoto S et al. (2008) Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem, 283:23139-49. (PubMed:18559345)
  52. Yu L et al. (2005) Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development, 132:4397-406. (PubMed:16141225)
  53. Zelarayan LC et al. (2007) Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. Dev Biol, 308:379-91. (PubMed:17601531)
  54. Zhang X et al. (2006) Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development, 133:173-80. (PubMed:16308329)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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