Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rgs5. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rgs5:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • GTPase activator activity
  • is located in the following cellular components:
    • cytoplasm
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Rgs5 encodes a protein or proteins that contain the following InterPro domains: Regulator of G protein signalling, Regulator of G protein signalling superfamily, Regulator of G-protein signaling, domain 1, indicating that the gene product:
  • participates in the following biological processes:
    • termination of G-protein coupled receptor signaling pathway

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rgs5 indicates that it:
  • participates in the following biological processes:
    • negative regulation of signal transduction
  • is located in the following cellular components:
    • membrane

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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