Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including disordered domain specific binding activity; transcription coactivator activity; and transcription factor binding activity. Predicted to contribute to DNA-binding transcription factor activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; face morphogenesis; and regulation of macromolecule biosynthetic process. Localizes to RNA polymerase II transcription regulator complex; condensed chromosome outer kinetochore; and nuclear lumen. Is expressed in several structures, including branchial arch; embryo ectoderm; genitourinary system; heart; and skin. Used to study Rubinstein-Taybi syndrome; acute myeloid leukemia; autism spectrum disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein).