Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables kinetochore binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of protein kinase activity; and regulation of mitotic metaphase/anaphase transition. Acts upstream of or within regulation of protein stability and spindle assembly involved in female meiosis I. Located in kinetochore. Part of outer kinetochore. Is expressed in testis and thymus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E).