Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kng1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Kng1:
  • participates in the following biological processes:
    • elevation of cytosolic calcium ion concentration
    • negative regulation of blood coagulation
    • negative regulation of cell adhesion
    • negative regulation of lymphocyte proliferation
    • negative regulation of MAP kinase activity
    • negative regulation of proteolysis
    • negative regulation of T cell proliferation
    • positive regulation of endothelial cell proliferation
    • positive regulation of fibroblast proliferation
    • positive regulation of MAPK cascade
    • regulation of endopeptidase activity
  • performs the following molecular functions:
    • cysteine-type endopeptidase inhibitor activity
    • protease binding
    • receptor binding
  • is located in the following cellular components:
    • extracellular space
    • intracellular membrane-bounded organelle
    • perikaryon

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kng1 indicates that it:
  • participates in the following biological processes:
    • blood coagulation
    • hemostasis
    • inflammatory response
    • negative regulation of peptidase activity
    • regulation of blood vessel size
    • vasodilation
  • performs the following molecular functions:
    • peptidase inhibitor activity
  • is located in the following cellular components:
    • extracellular region

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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