Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ogg1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ogg1
  • participates in the following biological processes:
    • base-excision repair ^[10]
  • performs the following molecular functions:
    • microtubule binding ^[2]
    • oxidized purine nucleobase lesion DNA N-glycosylase activity ^[10]
  • is located in the following cellular components:
    • mitochondrion ^{[6, 9]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ogg1
  • participates in the following biological processes:
    • base-excision repair ^[4]
    • DNA repair ^{[1, 7, 8, 11]}
  • performs the following molecular functions:
    • 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity ^[7]
    • oxidized purine nucleobase lesion DNA N-glycosylase activity ^[5]
  • is located in the following cellular components:
    • mitochondrion ^[3]
    • nucleus ^[5]
• Researchers have inferred, based on genetic interactions, that the gene product of Ogg1
  • participates in the following biological processes:
    • DNA repair based on interactions with Ercc6 ^{[7, 11]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ogg1:
  • participates in the following biological processes:
    • base-excision repair
    • regulation of protein import into nucleus, translocation
    • regulation of transcription, DNA-dependent
    • response to estradiol stimulus
    • response to oxidative stress
    • response to radiation
  • performs the following molecular functions:
    • damaged DNA binding
    • DNA N-glycosylase activity
    • oxidized purine nucleobase lesion DNA N-glycosylase activity
  • is located in the following cellular components:
    • mitochondrion
    • nuclear matrix
    • nuclear speck
    • nucleoplasm
    • nucleus

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Summary text based on GO annotations supported by structural data

• Ogg1 encodes a protein or proteins that contain the following InterPro domains: 8-oxoguanine DNA glycosylase, N-terminal, 8-oxoguanine DNA-glycosylase, DNA glycosylase, Helix-turn-helix, base-excision DNA repair, C-terminal, HhH-GPD domain, indicating that the gene product:
  • participates in the following biological processes:
    • nucleotide-excision repair
  • performs the following molecular functions:
    • catalytic activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ogg1 indicates that it:
  • participates in the following biological processes:
    • response to DNA damage stimulus
  • performs the following molecular functions:
    • catalytic activity
    • hydrolase activity
    • hydrolase activity, acting on glycosyl bonds
    • lyase activity
• Ogg1 has been associated with the Enzyme Commission numbers: 3.2.2.-, 4.2.99.18, which implies that the gene product:
  • performs the following molecular functions:
    • DNA-(apurinic or apyrimidinic site) lyase activity

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References

1. Arai T et al. (2003) Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA. Cancer Res, 63:4287-92. (PubMed:12874039)
2. Conlon KA et al. (2005) The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro. DNA Repair (Amst), 4:419-31. (PubMed:15725623)
3. de Souza-Pinto NC et al. (2001) Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice. Cancer Res, 61:5378-81. (PubMed:11454679)
4. Freedman SD et al. (1999) A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice. Proc Natl Acad Sci U S A, 96:13995-4000. (PubMed:10570187)
5. Klungland A et al. (1999) Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci U S A, 96:13300-5. (PubMed:10557315)
6. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
7. Osterod M et al. (2002) A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage. Oncogene, 21:8232-9. (PubMed:12447686)
8. Osterod M et al. (2001) Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice. Carcinogenesis, 22:1459-63. (PubMed:11532868)
9. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)
10. Rosenquist TA et al. (1997) Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc Natl Acad Sci U S A, 94:7429-34. (PubMed:9207108)
11. Trapp C et al. (2007) Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice. Oncogene, 26:4044-8. (PubMed:17213818)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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