Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ptpro. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ptpro
  • participates in the following biological processes:
    • negative regulation of canonical Wnt receptor signaling pathway ^[4]
    • peptidyl-tyrosine dephosphorylation ^[1]
  • performs the following molecular functions:
    • protein homodimerization activity ^[3]
    • protein tyrosine phosphatase activity ^[1]
    • Wnt-protein binding ^[4]
  • is located in the following cellular components:
    • apical plasma membrane ^[6]
    • dendritic spine ^[5]
    • lateral plasma membrane ^[6]
    • plasma membrane ^[1]
• The gene product of Ptpro has been shown to bind to the gene products of Grb2. ^{[1, 7]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ptpro
  • participates in the following biological processes:
    • axon guidance ^[2]
    • cell morphogenesis ^[7]
    • glomerular visceral epithelial cell differentiation ^[8]
    • lamellipodium assembly ^[7]
    • regulation of glomerular filtration ^[8]
    • slit diaphragm assembly ^[8]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ptpro:
  • participates in the following biological processes:
    • glomerulus development
    • monocyte chemotaxis
    • peptidyl-tyrosine dephosphorylation
  • performs the following molecular functions:
    • protein tyrosine phosphatase activity

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Summary text based on GO annotations supported by structural data

• Ptpro encodes a protein or proteins that contain the following InterPro domains: Fibronectin, type III, Immunoglobulin-like fold, Protein-tyrosine phosphatase, active site, Protein-tyrosine phosphatase, receptor/non-receptor type, Protein-tyrosine/Dual-specificity phosphatase, indicating that the gene product:
  • participates in the following biological processes:
    • dephosphorylation
    • protein dephosphorylation
  • performs the following molecular functions:
    • phosphatase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ptpro indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • phosphoprotein phosphatase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Chen B et al. (2005) A novel substrate of receptor tyrosine phosphatase PTPRO is required for nerve growth factor-induced process outgrowth. J Neurosci, 25:880-8. (PubMed:15673668)
2. Gonzalez-Brito MR et al. (2009) Protein tyrosine phosphatase receptor type O regulates development and function of the sensory nervous system. Mol Cell Neurosci, 42:458-65. (PubMed:19800005)
3. Hower AE et al. (2009) Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC. J Neurochem, 110:1635-47. (PubMed:19573017)
4. Kim M et al. (2010) Identification of ptpro as a novel target gene of Wnt signaling and its potential role as a receptor for Wnt. FEBS Lett, 584:3923-8. (PubMed:20804755)
5. Kotani T et al. (2010) Expression of PTPRO in the interneurons of adult mouse olfactory bulb. J Comp Neurol, 518:119-36. (PubMed:19924828)
6. Matozaki T et al. (2010) Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals. Cell Signal, 22:1811-7. (PubMed:20633639)
7. Murata Y et al. (2010) Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn. Genes Cells, 15:513-24. (PubMed:20398064)
8. Wharram BL et al. (2000) Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. J Clin Invest, 106:1281-90. (PubMed:11086029)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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