Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dll3. (This text reflects annotations as of Thursday, January 16, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Dll3
  • participates in the following biological processes:
    • negative regulation of neurogenesis ^[1]
    • somitogenesis ^[1]
    • tissue development ^[1]
• The gene product of Dll3 has been shown to bind to the gene products of Mib1. ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Dll3
  • participates in the following biological processes:
    • compartment pattern specification ^[5]
    • paraxial mesoderm development ^[4]
    • skeletal system development ^[2]
    • somitogenesis ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Dll3:
  • participates in the following biological processes:
    • negative regulation of astrocyte differentiation
    • negative regulation of Notch signaling pathway
    • positive regulation of neurogenesis
    • skeletal system development
  • performs the following molecular functions:
    • Notch binding

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Summary text based on GO annotations supported by structural data

• Dll3 encodes a protein or proteins that contain the following InterPro domains: EGF-like, conserved site, Epidermal growth factor-like domain, Insulin-like growth factor binding protein, N-terminal, Notch ligand, N-terminal, indicating that the gene product:
  • participates in the following biological processes:
    • multicellular organismal development
  • is located in the following cellular components:
    • integral component of membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Dll3 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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References

1. Dunwoodie SL et al. (1997) Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development, 124:3065-76. (PubMed:9272948)
2. Dunwoodie SL et al. (2002) Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development, 129:1795-806. (PubMed:11923214)
3. Koo BK et al. (2005) Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Development, 132:3459-70. (PubMed:16000382)
4. Kusumi K et al. (2004) Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes. Genesis, 39:115-21. (PubMed:15170697)
5. Zhang N et al. (2002) Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice. Genesis, 33:21-8. (PubMed:12001066)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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