Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Involved in several processes, including defense response to protozoan; mononuclear cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within chromatin remodeling; negative regulation of toll-like receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Part of nucleosome. Is expressed in several structures, including eye; hemolymphoid system; liver; mandible; and testis. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and pigmentation disease. Orthologous to human IRF4 (interferon regulatory factor 4).