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Gene Ontology Classifications
Symbol
Name
ID
Irf4
interferon regulatory factor 4
MGI:1096873

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Irf4. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Ciofani M et al. (2012) A validated regulatory network for th17 cell specification. Cell, 151:289-303. (PubMed:23021777)
  2. Glasmacher E et al. (2012) A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science, 338:975-80. (PubMed:22983707)
  3. Kernstock S et al. (2012) Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Nat Commun, 3:1038. (PubMed:22948820)
  4. Lazorchak AS et al. (2006) E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. Mol Cell Biol, 26:810-21. (PubMed:16428437)
  5. Li P et al. (2012) BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature, 490:543-6. (PubMed:22992523)
  6. Negishi H et al. (2005) Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A, 102:15989-94. (PubMed:16236719)
  7. Suzuki S et al. (2004) Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development. Proc Natl Acad Sci U S A, 101:8981-6. (PubMed:15184678)
  8. Tussiwand R et al. (2012) Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature, 490:502-7. (PubMed:22992524)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory