Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lasp1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Lasp1
  • performs the following molecular functions:
    • actin filament binding ^[1]
  • is located in the following cellular components:
    • cytoplasm ^[1]
    • focal adhesion ^[1]
• The gene product of Lasp1 has been shown to bind to the gene products of Ankrd54, Lpp, Vasp, Zyx. ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lasp1:
  • participates in the following biological processes:
    • ion transmembrane transport
    • ion transport
  • performs the following molecular functions:
    • ion transmembrane transporter activity
  • is located in the following cellular components:
    • cortical actin cytoskeleton

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Summary text based on GO annotations supported by structural data

• Lasp1 encodes a protein or proteins that contain the following InterPro domains: Nebulin 35 residue motif, Src homology-3 domain, Zinc finger, LIM-type, indicating that the gene product:
  • performs the following molecular functions:
    • zinc ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lasp1 indicates that it:
  • participates in the following biological processes:
    • transport
  • performs the following molecular functions:
    • actin binding
    • metal ion binding
  • is located in the following cellular components:
    • cytoskeleton

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References

1. Keicher C et al. (2004) Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. Biochem Biophys Res Commun, 324:308-16. (PubMed:15465019)
2. Samuels AL et al. (2009) Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Blood, 113:3845-56. (PubMed:19064729)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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