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Gene Ontology Classifications
snail family zinc finger 2

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Snai2. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of August 29, 2011. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Arnoux V et al. (2008) Erk5 controls Slug expression and keratinocyte activation during wound healing. Mol Biol Cell, 19:4738-49. (PubMed:18716062)
  2. Bell CE et al. (2009) SNAI1 and SNAI2 are asymmetrically expressed at the 2-cell stage and become segregated to the TE in the mouse blastocyst. PLoS One, 4:e8530. (PubMed:20046880)
  3. Inukai T et al. (1999) SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell, 4:343-52. (PubMed:10518215)
  4. Langer EM et al. (2008) Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. Dev Cell, 14:424-36. (PubMed:18331720)
  5. Murray SA et al. (2007) Multiple functions of Snail family genes during palate development in mice. Development, 134:1789-97. (PubMed:17376812)
  6. Newkirk KM et al. (2007) Snai2 expression enhances ultraviolet radiation-induced skin carcinogenesis. Am J Pathol, 171:1629-39. (PubMed:17916597)
  7. Niessen K et al. (2008) Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J Cell Biol, 182:315-25. (PubMed:18663143)
  8. Onodera T et al. (2010) Btbd7 regulates epithelial cell dynamics and branching morphogenesis. Science, 329:562-5. (PubMed:20671187)
  9. Perez-Losada J et al. (2003) The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug. Oncogene, 22:4205-11. (PubMed:12833143)
  10. Perez-Mancera PA et al. (2007) Adipose tissue mass is modulated by SLUG (SNAI2). Hum Mol Genet, 16:2972-86. (PubMed:17905753)
  11. Roman AC et al. (2008) Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo. Proc Natl Acad Sci U S A, 105:1632-7. (PubMed:18223155)
  12. Sanchez-Martin M et al. (2002) SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum Mol Genet, 11:3231-6. (PubMed:12444107)
  13. Savagner P et al. (1997) The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol, 137:1403-19. (PubMed:9182671)
  14. Sun Y et al. (2010) Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration. Blood, 115:1709-17. (PubMed:20032500)
  15. Wu WS et al. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell, 123:641-53. (PubMed:16286009)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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