Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ubiquitin protein ligase activity. Involved in negative regulation of interferon-beta production and protein ubiquitination. Acts upstream of or within signal transduction. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus and site of DNA damage. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina layer; and spleen. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein).