Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits ubiquitin protein ligase activity. Involved in protein ubiquitination; regulation of gene expression; and signal transduction. Predicted to localize to nucleolus; nucleoplasm; and site of DNA damage. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina layer; and spleen. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein).