Automated description from the Alliance of Genome Resources
Exhibits 3'-5' exonuclease activity. Involved in several processes, including G-quadruplex DNA unwinding; regulation of growth rate; and telomere maintenance. Localizes to the chromosome, telomeric region; nucleoplasm; and replication fork. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Is expressed in coelomic epithelium of testis; metanephros; and spleen. Orthologous to human WRN (WRN RecQ like helicase).