Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable several functions, including fructose-6-phosphate binding activity; glucose sensor activity; and kinase inhibitor activity. Acts upstream of or within intracellular glucose homeostasis and protein import into nucleus. Located in nucleus. Is expressed in diencephalon lateral wall mantle layer; liver left lobe; liver right lobe; midbrain mantle layer; and retina. Human ortholog(s) of this gene implicated in end stage renal disease and type 2 diabetes mellitus. Orthologous to human GCKR (glucokinase regulator).