Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Foxi1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it is possible that this gene plays an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Foxi1
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter ^[1]
    • positive regulation of transcription, DNA-dependent ^[3]
  • performs the following molecular functions:
    • sequence-specific DNA binding ^[3]
    • transcription regulatory region DNA binding ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Foxi1
  • participates in the following biological processes:
    • inner ear morphogenesis ^[2]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Foxi1
  • is located in the following cellular components:
    • nucleus ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Foxi1:
  • participates in the following biological processes:
    • epidermal cell fate specification
    • negative regulation of transcription from RNA polymerase II promoter
    • otic placode formation
    • pattern specification process
    • positive regulation of transcription from RNA polymerase II promoter
    • regulation of sequence-specific DNA binding transcription factor activity
  • performs the following molecular functions:
    • DNA binding, bending
    • double-stranded DNA binding
    • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
    • sequence-specific DNA binding transcription factor activity
    • transcription factor binding
  • is located in the following cellular components:
    • transcription factor complex

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Summary text based on GO annotations supported by structural data

• Foxi1 encodes a protein or proteins that contain the following InterPro domains: Transcription factor, fork head, Transcription factor, fork head, conserved site, Winged helix-turn-helix transcription repressor DNA-binding, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Foxi1 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding

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References

1. Clevidence DE et al. (1994) Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter. Dev Biol, 166:195-209. (PubMed:7958446)
2. Hulander M et al. (2003) Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development, 130:2013-25. (PubMed:12642503)
3. Kurth I et al. (2006) The forkhead transcription factor Foxi1 directly activates the AE4 promoter. Biochem J, 393:277-83. (PubMed:16159312)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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