Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mesp2. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Mesp2
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter ^[3]
    • signal transduction involved in regulation of gene expression ^[2]
  • performs the following molecular functions:
    • DNA binding ^[3]
    • sequence-specific DNA binding transcription factor activity ^[3]
  • is located in the following cellular components:
    • nucleus ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mesp2
  • participates in the following biological processes:
    • somitogenesis ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Mesp2
  • participates in the following biological processes:
    • mesodermal cell migration based on interactions with Dll1 ^[1]
    • Notch signaling pathway based on interactions with Dll1 ^[3]
    • somitogenesis based on interactions with Dll1 ^[3]

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Summary text based on GO annotations supported by structural data

• Mesp2 encodes a protein or proteins that contain the following InterPro domains: Myc-type, basic helix-loop-helix (bHLH) domain, indicating that the gene product:
  • performs the following molecular functions:
    • protein dimerization activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mesp2 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent

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References

1. Kitajima S et al. (2000) MesP1 and MesP2 are essential for the development of cardiac mesoderm. Development, 127:3215-26. (PubMed:10887078)
2. Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell, 2:497-507. (PubMed:18462699)
3. Morimoto M et al. (2005) The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature, 435:354-9. (PubMed:15902259)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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