Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Faah. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Faah
  • performs the following molecular functions:
    • acylglycerol lipase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Faah:
  • participates in the following biological processes:
    • fatty acid catabolic process
    • fatty acid metabolic process
  • performs the following molecular functions:
    • amidase activity
    • fatty acid amide hydrolase activity
    • hydrolase activity, acting on ester bonds
    • lipid binding
    • phospholipid binding
    • protein homodimerization activity
  • is located in the following cellular components:
    • cytoplasm
    • organelle membrane

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Summary text based on GO annotations supported by structural data

• Faah encodes a protein or proteins that contain the following InterPro domains: Amidase, Amidase signature domain, Amidase, conserved site, Amidase, fungi, indicating that the gene product:
  • performs the following molecular functions:
    • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Faah indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
  • is located in the following cellular components:
    • endoplasmic reticulum
    • Golgi apparatus
    • integral to membrane
    • membrane

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References

1. Marrs WR et al. (2010) The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci, 13:951-7. (PubMed:20657592)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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