Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Terc. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Telomerase may also participate in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. In contrast with human telomerase, murine telomerase is expressed in many normal postnatal somatic tissues. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Terc
  • participates in the following biological processes:
    • cell proliferation ^[6]
    • hematopoietic stem cell differentiation ^[6]
    • negative regulation of apoptotic process ^[6]
    • positive regulation of telomere maintenance via telomerase ^[4]
    • post-embryonic development ^[6]
    • telomere maintenance ^[5]
    • telomere maintenance via telomerase ^[3]
  • performs the following molecular functions:
    • telomerase activity ^[4]
    • template for synthesis of G-rich strand of telomere DNA activity ^[3]
  • is located in the following cellular components:
    • telomerase holoenzyme complex ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Terc
  • participates in the following biological processes:
    • multicellular organismal aging based on interactions with Wrn ^[1]
    • regulation of cell proliferation based on interactions with Apc ^[7]
    • telomere maintenance based on interactions with Blm, Wrn ^{[1, 2]}

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References

1. Chang S et al. (2004) Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet, 36:877-82. (PubMed:15235603)
2. Du X et al. (2004) Telomere shortening exposes functions for the mouse werner and bloom syndrome genes. Mol Cell Biol, 24:8437-46. (PubMed:15367665)
3. Elenius K et al. (1997) A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem, 272:26761-8. (PubMed:9334263)
4. Liu L et al. (2007) Telomere lengthening early in development. Nat Cell Biol, 9:1436-41. (PubMed:17982445)
5. Maser RS et al. (2007) DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol Cell Biol, 27:2253-65. (PubMed:17145779)
6. Rossi DJ et al. (2007) Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature, 447:725-9. (PubMed:17554309)
7. Rudolph KL et al. (2001) Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet, 28:155-9. (PubMed:11381263)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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