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Gene Ontology Classifications
Symbol
Name
ID
Terc
telomerase RNA component
MGI:109558

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Terc. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Telomerase may also participate in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. In contrast with human telomerase, murine telomerase is expressed in many normal postnatal somatic tissues. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
References
  1. Chang S et al. (2004) Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet, 36:877-82. (PubMed:15235603)
  2. Du X et al. (2004) Telomere shortening exposes functions for the mouse werner and bloom syndrome genes. Mol Cell Biol, 24:8437-46. (PubMed:15367665)
  3. Elenius K et al. (1997) A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem, 272:26761-8. (PubMed:9334263)
  4. Liu L et al. (2007) Telomere lengthening early in development. Nat Cell Biol, 9:1436-41. (PubMed:17982445)
  5. Maser RS et al. (2007) DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol Cell Biol, 27:2253-65. (PubMed:17145779)
  6. Rossi DJ et al. (2007) Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature, 447:725-9. (PubMed:17554309)
  7. Rudolph KL et al. (2001) Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet, 28:155-9. (PubMed:11381263)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory