Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ctsc. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ctsc
  • participates in the following biological processes:
    • proteolysis ^[1]
  • performs the following molecular functions:
    • serine-type endopeptidase activity ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Ctsc
  • participates in the following biological processes:
    • T cell mediated cytotoxicity based on interactions with Ctsh ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ctsc:
  • participates in the following biological processes:
    • proteolysis
    • response to organic substance
  • performs the following molecular functions:
    • chloride ion binding
    • cysteine-type peptidase activity
    • identical protein binding
    • protein self-association
  • is located in the following cellular components:
    • endoplasmic reticulum
    • Golgi apparatus
    • lysosome

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ctsc indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • peptidase activity

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References

1. D'Angelo ME et al. (2010) Cathepsin H is an additional convertase of pro-granzyme B. J Biol Chem, 285:20514-9. (PubMed:20435891)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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