Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables peptidase activity; protein homodimerization activity; and protein kinase binding activity. Involved in several processes, including protein catabolic process at postsynapse; proteolysis; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within protein processing. Located in several cellular components, including cell surface; postsynaptic density; and synaptic membrane. Part of pore complex. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; foregut-midgut junction; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10).