Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Slc2a2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Slc2a2
  • participates in the following biological processes:
    • dehydroascorbic acid transport ^[1]
    • glucose transport ^[1]
    • hexose transmembrane transport ^[1]
    • transmembrane transport ^[1]
  • performs the following molecular functions:
    • D-glucose transmembrane transporter activity ^[1]
    • dehydroascorbic acid transporter activity ^[1]
  • is located in the following cellular components:
    • brush border ^[4]
    • cytoplasm ^[1]
    • plasma membrane ^{[2, 3, 5]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Slc2a2:
  • participates in the following biological processes:
    • carbohydrate utilization
    • dehydroascorbic acid transport
    • glucose transport
  • performs the following molecular functions:
    • D-glucose transmembrane transporter activity
    • dehydroascorbic acid transporter activity
    • glucose transmembrane transporter activity
    • insulin receptor binding
  • is located in the following cellular components:
    • basolateral plasma membrane
    • brush border
    • brush border membrane
    • cytoplasm
    • cytosol
    • endosome
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Slc2a2 encodes a protein or proteins that contain the following InterPro domains: General substrate transporter, Glucose transporter, type 2 (GLUT2), Major facilitator superfamily domain, Major facilitator superfamily domain, general substrate transporter, Sugar transporter, conserved site, Sugar/inositol transporter, indicating that the gene product:
  • participates in the following biological processes:
    • transport
  • performs the following molecular functions:
    • substrate-specific transmembrane transporter activity
    • transmembrane transporter activity
    • transporter activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Slc2a2 indicates that it:
  • participates in the following biological processes:
    • transport
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Angulo C et al. (2008) Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells. J Cell Physiol, 217:708-16. (PubMed:18668520)
2. Hald J et al. (2003) Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol, 260:426-37. (PubMed:12921743)
3. Harndahl L et al. (2004) Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology. J Biol Chem, 279:15214-22. (PubMed:14736883)
4. Osswald C et al. (2005) Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol Cell Biol, 25:78-87. (PubMed:15601832)
5. Sumazaki R et al. (2004) Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat Genet, 36:83-7. (PubMed:14702043)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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