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Gene Ontology Classifications
synaptonemal complex protein 3

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sycp3. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Baarends WM et al. (2005) Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol Cell Biol, 25:1041-53. (PubMed:15657431)
  2. Berkowitz KM et al. (2012) Disruption of CHTF18 causes defective meiotic recombination in male mice. PLoS Genet, 8:e1002996. (PubMed:23133398)
  3. Beyret E et al. (2011) Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Dev Biol, 355:215-26. (PubMed:21539824)
  4. Di Carlo AD et al. (2000) The meiotic specific synaptonemal complex protein SCP3 is expressed by female and male primordial germ cells of the mouse embryo. Int J Dev Biol, 44:241-4. (PubMed:10794082)
  5. Guiraldelli MF et al. (2013) Mouse HFM1/Mer3 Is Required for Crossover Formation and Complete Synapsis of Homologous Chromosomes during Meiosis. PLoS Genet, 9:e1003383. (PubMed:23555294)
  6. Hamer G et al. (2006) Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex. J Cell Sci, 119:4025-32. (PubMed:16968740)
  7. Herran Y et al. (2011) The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility. EMBO J, 30:3091-105. (PubMed:21743440)
  8. Holloway JK et al. (2014) Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. J Cell Biol, 205:633-41. (PubMed:24891606)
  9. Hosokawa M et al. (2007) Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. Dev Biol, 301:38-52. (PubMed:17141210)
  10. Ishiguro K et al. (2014) Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes Dev, 28:594-607. (PubMed:24589552)
  11. Jordan PW et al. (2012) Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J Cell Sci, 125:5061-72. (PubMed:22854038)
  12. Kim J et al. (2014) Meikin is a conserved regulator of meiosis-I-specific kinetochore function. Nature, null:null. (PubMed:25533956)
  13. Kneitz B et al. (2000) MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev, 14:1085-97. (PubMed:10809667)
  14. Kouznetsova A et al. (2011) Meiosis in mice without a synaptonemal complex. PLoS One, 6:e28255. (PubMed:22164254)
  15. Kouznetsova A et al. (2005) SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division. J Cell Sci, 118:2271-8. (PubMed:15870106)
  16. Krentz AD et al. (2011) DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary. Dev Biol, 356:63-70. (PubMed:21621532)
  17. Kudo NR et al. (2009) Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I. J Cell Sci, 122:2686-98. (PubMed:19625504)
  18. Kumar R et al. (2010) Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev, 24:1266-80. (PubMed:20551173)
  19. Kuramochi-Miyagawa S et al. (2004) Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development, 131:839-49. (PubMed:14736746)
  20. Kwan KY et al. (2003) Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta. Proc Natl Acad Sci U S A, 100:2526-31. (PubMed:12591952)
  21. La Salle S et al. (2012) Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells. Biol Reprod, 86:45. (PubMed:22011390)
  22. Lee J et al. (2003) Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis. J Cell Sci, 116:2781-90. (PubMed:12759374)
  23. Li X et al. (2007) Mouse Pachytene Checkpoint 2 (Trip13) Is Required for Completing Meiotic Recombination but Not Synapsis. PLoS Genet, 3:e130. (PubMed:17696610)
  24. Lipkin SM et al. (2002) Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet, 31:385-90. (PubMed:12091911)
  25. Llano E et al. (2012) Meiotic cohesin complexes are essential for the formation of the axial element in mice. J Cell Biol, 197:877-85. (PubMed:22711701)
  26. Ollinger R et al. (2008) Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice. PLoS Genet, 4:e1000199. (PubMed:18802469)
  27. Parra MT et al. (2009) Sequential assembly of centromeric proteins in male mouse meiosis. PLoS Genet, 5:e1000417. (PubMed:19283064)
  28. Paul C et al. (2007) Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS ONE, 2:e989. (PubMed:17912366)
  29. Ryu KY et al. (2008) The mouse polyubiquitin gene Ubb is essential for meiotic progression. Mol Cell Biol, 28:1136-46. (PubMed:18070917)
  30. Shi YQ et al. (2013) SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60. Gene, 527:352-9. (PubMed:23810942)
  31. Tay J et al. (2003) Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation. Genes Dev, 17:1457-62. (PubMed:12815066)
  32. Ward JO et al. (2007) Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over. PLoS Genet, 3:e139. (PubMed:17784788)
  33. Wesoly J et al. (2006) Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol, 26:976-89. (PubMed:16428451)
  34. Yang F et al. (2008) Meiotic failure in male mice lacking an X-linked factor. Genes Dev, 22:682-91. (PubMed:18316482)
  35. Yang F et al. (2006) Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol, 173:497-507. (PubMed:16717126)
  36. Yuan L et al. (2000) The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility. Mol Cell, 5:73-83. (PubMed:10678170)
  37. Yuan L et al. (2002) Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3. Science, 296:1115-8. (PubMed:12004129)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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