Automated description from the Alliance of Genome Resources
Exhibits DNA binding activity; histone demethylase activity (H3-K27 specific); and identical protein binding activity. Involved in several processes, including chordate embryonic development; chromatin organization; and embryonic morphogenesis. Localizes to the histone methyltransferase complex. Used to study chronic myelomonocytic leukemia. Human ortholog(s) of this gene implicated in Kabuki syndrome; esophagus squamous cell carcinoma; and precursor lymphoblastic lymphoma/leukemia. Orthologous to human KDM6A (lysine demethylase 6A).