Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA binding activity; histone H3K27me2/H3K27me3 demethylase activity; and identical protein binding activity. Involved in chromatin remodeling. Acts upstream of or within several processes, including chordate embryonic development; embryonic morphogenesis; and respiratory system process. Located in nucleus. Part of histone methyltransferase complex. Is expressed in several structures, including alimentary system; early conceptus; gonad; liver; and spleen. Used to study chronic myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to human KDM6A (lysine demethylase 6A).