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Gene Ontology Classifications
bone morphogenetic protein receptor, type II (serine/threonine kinase)

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GO curators for mouse genes have assigned the following annotations to the gene product of Bmpr2. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Beppu H et al. (2000) BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol, 221:249-58. (PubMed:10772805)
  2. Engelhard C et al. (2013) MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. Elife, 2:e01160. (PubMed:24052814)
  3. Faber SC et al. (2002) Bmp signaling is required for development of primary lens fiber cells. Development, 129:3727-37. (PubMed:12117821)
  4. Kelly CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol, 11:e1001538. (PubMed:23610558)
  5. Munton RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics, 6:283-93. (PubMed:17114649)
  6. Nagashima T et al. (2013) BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J Clin Invest, 123:2539-50. (PubMed:23676498)
  7. Niessen K et al. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood, 115:1654-61. (PubMed:19903896)
  8. Park S et al. (2004) B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol Cell Biol, 24:10256-62. (PubMed:15542835)
  9. Schwappacher R et al. (2009) Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity. EMBO J, 28:1537-50. (PubMed:19424179)
  10. Song Y et al. (2008) Inflammation, Endothelial Injury, and Persistent Pulmonary Hypertension in Heterozygous BMPR2-Mutant Mice. Am J Physiol Heart Circ Physiol, null:null. (PubMed:18552156)
  11. Xia Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem, 282:18129-40. (PubMed:17472960)

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Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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