Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bmpr2. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Bmpr2
  • is located in the following cellular components:
    • cell surface ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Bmpr2
  • participates in the following biological processes:
    • anterior/posterior pattern specification ^[1]
    • artery development ^[3]
    • blood vessel remodeling ^[3]
    • BMP signaling pathway ^[6]
    • lung alveolus development ^[5]
    • lymphangiogenesis ^[3]
    • lymphatic endothelial cell differentiation ^[3]
    • mesoderm formation ^[1]
    • negative regulation of vasoconstriction ^[5]
    • regulation of lung blood pressure ^[5]
    • retina vasculature development in camera-type eye ^[3]
    • vascular endothelial growth factor receptor signaling pathway ^[5]
    • venous blood vessel development ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Bmpr2
  • participates in the following biological processes:
    • anterior/posterior pattern specification based on interactions with Acvr2b ^[4]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Bmpr2:
  • participates in the following biological processes:
    • BMP signaling pathway
    • negative regulation of cell growth
    • negative regulation of DNA biosynthetic process
    • negative regulation of systemic arterial blood pressure
    • positive regulation of BMP signaling pathway
    • positive regulation of bone mineralization
    • positive regulation of endothelial cell migration
    • positive regulation of endothelial cell proliferation
    • positive regulation of epithelial cell migration
    • positive regulation of osteoblast differentiation
    • positive regulation of pathway-restricted SMAD protein phosphorylation
    • positive regulation of protein phosphorylation
    • protein phosphorylation
    • regulation of cell proliferation
    • regulation of lung blood pressure
    • transcription from RNA polymerase II promoter
    • transmembrane receptor protein serine/threonine kinase signaling pathway
  • performs the following molecular functions:
    • growth factor binding
    • transmembrane receptor protein serine/threonine kinase activity
  • is located in the following cellular components:
    • apical plasma membrane
    • basal plasma membrane
    • caveola
    • cytoplasm
    • dendrite
    • integral to plasma membrane
    • neuronal cell body
    • plasma membrane

---

Summary text based on GO annotations supported by structural data

• Bmpr2 encodes a protein or proteins that contain the following InterPro domains: Bone morphogenic protein type II receptor, Protein kinase, ATP binding site, Protein kinase, catalytic domain, Protein kinase-like domain, TGF-beta receptor/activin receptor, type I/II, indicating that the gene product:
  • participates in the following biological processes:
    • protein phosphorylation
    • transmembrane receptor protein serine/threonine kinase signaling pathway
  • performs the following molecular functions:
    • ATP binding
    • protein kinase activity
    • transferase activity, transferring phosphorus-containing groups
    • transforming growth factor beta-activated receptor activity
  • is located in the following cellular components:
    • membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Bmpr2 indicates that it:
  • participates in the following biological processes:
    • phosphorylation
    • protein phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • metal ion binding
    • nucleotide binding
    • protein serine/threonine kinase activity
    • transferase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

---

References

1. Beppu H et al. (2000) BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol, 221:249-58. (PubMed:10772805)
2. Faber SC et al. (2002) Bmp signaling is required for development of primary lens fiber cells. Development, 129:3727-37. (PubMed:12117821)
3. Niessen K et al. (2010) ALK1 signaling regulates early postnatal lymphatic vessel development. Blood, 115:1654-61. (PubMed:19903896)
4. Park S et al. (2004) B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol Cell Biol, 24:10256-62. (PubMed:15542835)
5. Song Y et al. (2008) Inflammation, Endothelial Injury, and Persistent Pulmonary Hypertension in Heterozygous BMPR2-Mutant Mice. Am J Physiol Heart Circ Physiol, null:null. (PubMed:18552156)
6. Xia Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem, 282:18129-40. (PubMed:17472960)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---