Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables store-operated calcium channel activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Located in plasma membrane and slit diaphragm. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver and biliary system; and nervous system. Human ortholog(s) of this gene implicated in chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6).