Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Htr2a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Htr2a:
  • participates in the following biological processes:
    • cell death
    • ERK1 and ERK2 cascade
    • G-protein coupled receptor signaling pathway
    • memory
    • negative regulation of potassium ion transport
    • negative regulation of synaptic transmission, glutamatergic
    • phosphatidylinositol 3-kinase cascade
    • phosphatidylinositol biosynthetic process
    • phospholipase C-activating serotonin receptor signaling pathway
    • positive regulation of cell proliferation
    • positive regulation of MAP kinase activity
    • positive regulation of vasoconstriction
    • regulation of dopamine secretion
    • release of sequestered calcium ion into cytosol
    • response to drug
    • response to stress
    • sensory perception of pain
    • serotonin receptor signaling pathway
    • sleep
    • temperature homeostasis
  • performs the following molecular functions:
    • 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
    • drug binding
    • G-protein alpha-subunit binding
    • phosphatidylinositol phospholipase C activity
    • protein complex binding
    • serotonin binding
    • serotonin receptor activity
  • is located in the following cellular components:
    • cytoplasm
    • cytosol
    • dendrite
    • dendritic shaft
    • membrane
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Htr2a encodes a protein or proteins that contain the following InterPro domains: 5-Hydroxytryptamine 2A receptor, 5-Hydroxytryptamine receptor, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Htr2a indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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