Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits high voltage-gated calcium channel activity and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including cellular ion homeostasis; chemical synaptic transmission; and nervous system development. Localizes to several cellular components, including glutamatergic synapse; neuronal cell body; and voltage-gated calcium channel complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; and trigeminal nerve. Used to study Lambert-Eaton myasthenic syndrome; brain disease (multiple); and episodic ataxia type 2. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 42; hereditary ataxia (multiple); and migraine (multiple). Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A).