Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cfc1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cfc1
  • participates in the following biological processes:
    • BMP signaling pathway ^[2]
    • canonical Wnt receptor signaling pathway ^[2]
• Researchers have inferred, based on physical interactions, that the gene product of Cfc1
  • performs the following molecular functions:
    • activin receptor binding ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cfc1
  • participates in the following biological processes:
    • atrial septum morphogenesis ^[3]
    • determination of left/right symmetry ^[3]
    • digestive tract morphogenesis ^[3]
    • heart looping ^[3]
    • heart morphogenesis ^[3]
    • left lung morphogenesis ^[3]
    • liver development ^[3]
    • nodal signaling pathway ^[4]
    • post-embryonic development ^[3]
    • respiratory system development ^[3]
    • spleen development ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Cfc1
  • participates in the following biological processes:
    • anatomical structure development based on interactions with ^[1]
    • anterior/posterior pattern specification based on interactions with ^[1]
    • endoderm development based on interactions with ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cfc1:
  • participates in the following biological processes:
    • nodal signaling pathway
  • performs the following molecular functions:
    • nodal binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cfc1 indicates that it:
  • participates in the following biological processes:
    • gastrulation
    • multicellular organismal development
  • is located in the following cellular components:
    • anchored to membrane
    • extracellular region
    • membrane
    • plasma membrane

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References

1. Kimura C et al. (2001) Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast. Dev Biol, 235:12-32. (PubMed:11412024)
2. Liu Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A, 104:3859-64. (PubMed:17360443)
3. Yan YT et al. (1999) Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes Dev, 13:2527-37. (PubMed:10521397)
4. Yan YT et al. (2002) Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. Mol Cell Biol, 22:4439-49. (PubMed:12052855)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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