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Gene Ontology Classifications
estrogen receptor 2 (beta)

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GO curators for mouse genes have assigned the following annotations to the gene product of Esr2. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Balla A et al. (2003) Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve. Biol Reprod, 69:1281-93. (PubMed:12801993)
  2. Danilovich N et al. (2003) The menopausal mouse: a new neural paradigm of a distressing human condition. Neuroreport, 14:1617-22. (PubMed:14502087)
  3. Danilovich N et al. (2003) Age-related neurodegenerative changes in the central nervous system of estrogen-deficient follitropin receptor knockout mice. Exp Neurol, 183:559-72. (PubMed:14552897)
  4. Di Cristofano A et al. (1998) Pten is essential for embryonic development and tumour suppression. Nat Genet, 19:348-55. (PubMed:9697695)
  5. Dupont S et al. (2000) Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development, 127:4277-91. (PubMed:10976058)
  6. Giroux V et al. (2008) Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice. Int J Cancer, 123:303-11. (PubMed:18464259)
  7. Imamov O et al. (2004) Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate. Proc Natl Acad Sci U S A, 101:9375-80. (PubMed:15187231)
  8. Jung DJ et al. (2002) Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors. J Biol Chem, 277:1229-34. (PubMed:11704680)
  9. Krege JH et al. (1998) Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A, 95:15677-82. (PubMed:9861029)
  10. Saijo K et al. (2011) An ADIOL-ERbeta-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell, 145:584-95. (PubMed:21565615)
  11. Tremblay GB et al. (1997) Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol, 11:353-65. (PubMed:9058381)
  12. Wang L et al. (2003) Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain. Proc Natl Acad Sci U S A, 100:703-8. (PubMed:12515851)
  13. Weihua Z et al. (2002) An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci U S A, 99:13589-94. (PubMed:12370428)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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