Automated description from the Alliance of Genome Resources (Release 5.3.0)
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of ERK1 and ERK2 cascade; and regulation of gene expression. Acts upstream of or within gluconeogenesis; negative regulation of DNA-templated transcription; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and limb long bone. Orthologous to human ATF3 (activating transcription factor 3).