Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hmox2. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Alternative splice variants encoding the same protein have been identified at this locus. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Hmox2:
  • participates in the following biological processes:
    • oxidation-reduction process
    • response to hypoxia
    • response to oxidative stress
  • performs the following molecular functions:
    • heme oxygenase (decyclizing) activity
  • is located in the following cellular components:
    • plasma membrane

---

Summary text based on GO annotations supported by structural data

• Hmox2 encodes a protein or proteins that contain the following InterPro domains: Haem oxygenase, Haem oxygenase conserved site, Haem oxygenase-like, Haem oxygenase-like, multi-helical, indicating that the gene product:
  • participates in the following biological processes:
    • heme oxidation

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Hmox2 indicates that it:
  • performs the following molecular functions:
    • metal ion binding
    • oxidoreductase activity
  • is located in the following cellular components:
    • endoplasmic reticulum
    • intracellular membrane-bounded organelle

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---