Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and protein dimerization activity. Involved in several processes, including growth plate cartilage development; hindbrain development; and intracellular signal transduction. Acts upstream of or within with a positive effect on cellular response to leucine starvation and regulation of transcription by RNA polymerase II. Acts upstream of or within adipose tissue development; outflow tract morphogenesis; and positive regulation of macromolecule biosynthetic process. Located in membrane; nucleus; and site of double-strand break. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Used to study meconium aspiration syndrome and osteochondrodysplasia. Orthologous to human ATF2 (activating transcription factor 2).