Automated description from the Alliance of Genome Resources
Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including animal organ development; circulatory system development; and embryonic hindlimb morphogenesis. Localizes to the cytoplasm; nucleus; and transcription factor complex. Used to study Axenfeld-Rieger syndrome type 1 and glaucoma. Human ortholog(s) of this gene implicated in Arts syndrome; Axenfeld-Rieger syndrome; and Axenfeld-Rieger syndrome type 1. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and musculature. Orthologous to human PITX2 (paired like homeodomain 2).